Publication - 9
CASE REPORT
Modifying Standard Dose of PRP for Long-term Clinical Outcome of MSK Pathologies
Methods: After undergoing conventional treatment modalities, a patient underwent a course of ultrasound guided PRP injection followed by physical therapy (core strengthening) for 10 weeks.
The patient outcome was measured using the numerical Pain Rating Scale (NPRS), Oxford Scoring System (OSS), and the Western Ontario and McMaster Universities Arthritis (WOMAC) Index. Radiological examination using Magnetic Resonance Imaging (MRI) was also performed before and
after PRP treatment.
Results: Following treatment, the patient reported pain relief within a week. As the patient continued core strengthening exercise for 10 weeks, he showed drastic improvement in function with no pain and discomfort as determined by NPRS, OSS, and WOMAC index respectively. At the same time, there were no significant complications. Even the repeat MRI performed after 18 m showed no supraspinatus tendinopathy tear.
Conclusion: In this case report, PRP injections in combination with physical therapy for the treatment of rotator cuff tendinopathy demonstrated improvement in all outcome measures. This highlights the need for conducting more controlled trials to determine the effect of this combinational treatment.
Abstract: Currently, platelet-rich plasma (PRP) stands as a widely adopted treatment for musculoskeletal issues. Despite promising outcomes linked to PRP application in these conditions, crucial questions persist, such as definitive proof of its effectiveness in altering structures, establishing standard dosages, and devising optimal manual preparation methods to yield high-quality PRP. This review focuses on four key topics regarding the use of PRP in managing musculoskeletal ailments: (a) exploring PRP’s composition and its significance, (b) assessing evidence supporting its effectiveness in treating injuries to tendons, joints, ligaments, and muscles, (c) comparing available PRP kits to gauge their cell count variations, and (d) emphasizing the importance of optimizing PRP dosage and its connection to both structural and physiological efficacy on an individual basis.
Keywords: Platelet-rich plasma, PRP, Musculoskeletal pathologies, Dose optimization
Introduction:Musculoskeletal (MSK) diseases stand as a leading cause of prolonged, intense pain and significant physical limitations, significantly impacting patients’ quality of life [1-3]. This type of pain affects a vast number of individuals worldwide, nearly hundreds of millions [1,4]. Typical approaches to managing MSK pain involve traditional methods like “Rest, Ice, Compression, Elevation” therapy alongside physical therapy, corticosteroid injections, and specific rehabilitative exercises [1,5]. While these methods often aid in short-term pain relief and early functional recovery, they generally do not reverse the structural changes linked to degenerative conditions. PRP (Platelets Rich Plasma) an orthobiological application has shown promising results in aiding the body to regenerate functional tissues for restoring degenerative or defective areas.
